Research Areas

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Structure-Guided Inhibitor Design on RNA Modifying Proteins

We determine structures of protein-inhibitor complexes using X-ray crystallography to guide development of anti-cancer and anti-viral compounds. We focus primarily on DNA or RNA binding proteins, which play important roles in gene regulation and disease development.

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Structural Biology of Protein-RNA Complexes

We are intrigued by how proteins regulate genes on the RNA transcript level, especially through post-transcriptional modifications. In this area of research, we investigate how molecular machines that modify RNA using structural biology techniques such as protein crystallography and cryo-electron microscopy. We are also interested in investigating how viruses modify RNA.

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Macromolecular Assembly Engineering

We are also exploring the use of macromolecules as drug delivery agents. We take advantage of structural biology and biophysical techniques to guide our design.