Publications

 
  1. Sun, Y., Zhang, Y., Aik, W.S., Yang, X., Marzluff, W.F., Walz, T., Dominski, Z., Tong, L. Structure of an active human histone pre-mRNA 3’-end processing machinery (2020) Science, 367 (6478), pp. 700-703.

  2. Bucholc, K., Aik, W.S., Yang, X., Wang, K., Zhou Z.H., Dadlez, M., Marzluff W.F., Tong, L., Dominski, Z. Composition and processing activity of a semi-recombinant holo U7 snRNP (2020) Nucleic Acids Research, 48 (3), pp. 1508-1530.

  3. Aik, W.S., Lin, M.-H., Tan, D., Tripathy, A., Marzluff, W.F., Dominski, Z., Chou, C.-Y., Tong, L. The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3’-end processing (2017) PLoS ONE, 12 (10), art. no. e0186034.

  4. Horita, S., Scotti, J.S., Thinnes, C., Mottaghi-Taromsari, Y.S., Thalhammer, A., Ge, W., Aik, W., Loenarz, C., Schofield, C.J., McDonough, M.A. Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases (2015) Structure, 23 (4), pp. 639-652.

  5. McMurray, F., Demetriades, M., Aik, W., Merkestein, M., Kramer, H., Andrew, D.S., Scudamore, C.L., Hough, T.A., Wells, S., Ashcroft, F.M., McDonough, M.A., Schofield, C.J., Cox, R.D. Pharmacological inhibition of FTO (2015) PLoS ONE, 10 (4), art. no. e0121829.

  6. Aik, W.S., Chowdhury, R., Clifton, I.J., Hopkinson, R.J., Leissing, T., McDonough, M.A., Nowak, R., Schofield, C.J., Walport, L.J. Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes (2015) RSC Metallobiology, 2015-January (3), pp. 59-94.

  7. Scotti, J.S., Leung, I.K.H., Ge, W., Bentley, M.A., Paps, J., Kramer, H.B., Lee, J., Aik, W., Choi, H., Paulsen, S.M., Bowman, L.A.H., Loik, N.D., Horita, S., Ho, C.-H., Kershaw, N.J., Tang, C.M., Claridge, T.D.W., Preston, G.M., McDonough, M.A., Schofield, C.J. Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation (2014) Proceedings of the National Academy of Sciences of the United States of America, 111 (37), pp. 13331-13336.

  8. Xu, C., Liu, K., Tempel, W., Demetriades, M., Aik, W., Schofield, C.J., Min, J. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation (2014) Journal of Biological Chemistry, 289 (25), pp. 17299-17311.

  9. Aik, W., Scotti, J.S., Choi, H., Gong, L., Demetriades, M., Schofield, C.J., McDonough, M.A. Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation (2014) Nucleic Acids Research, 42 (7), pp. 4741-4754.

  10. Brem, J., Van Berkel, S.S., Aik, W., Rydzik, A.M., Avison, M.B., Pettinati, I., Umland, K.-D., Kawamura, A., Spencer, J., Claridge, T.D.W., McDonough, M.A., Schofield, C.J. Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β 2-lactamase inhibition (2014) Nature Chemistry, 6 (12), pp. 1084-1090.

  11. Hopkinson, R.J., Tumber, A., Yapp, C., Chowdhury, R., Aik, W., Che, K.H., Li, X.S., Kristensen, J.B.L., King, O.N.F., Chan, M.C., Yeoh, K.K., Choi, H., Walport, L.J., Thinnes, C.C., Bush, J.T., Lejeune, C., Rydzik, A.M., Rose, N.R., Bagg, E.A., McDonough, M.A., Krojer, T.J., Yue, W.W., Ng, S.S., Olsen, L., Brennan, P.E., Oppermann, U., Müller, S., Klose, R.J., Ratcliffe, P.J., Schofield, C.J., Kawamura, A. 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation (2013) Chemical Science, 4 (8), pp. 3110-3117.

  12. Aik, W., Demetriades, M., Hamdan, M.K.K., Bagg, E.A.L., Yeoh, K.K., Lejeune, C., Zhang, Z., McDonough, M.A., Schofield, C.J. Structural basis for inhibition of the fat mass and obesity associated protein (FTO) (2013) Journal of Medicinal Chemistry, 56 (9), pp. 3680-3688.

  13. Aik, W., McDonough, M.A., Thalhammer, A., Chowdhury, R., Schofield, C.J. Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases (2012) Current Opinion in Structural Biology, 22 (6), pp. 691-700.

  14. Woon, E.C.Y., Demetriades, M., Bagg, E.A.L., Aik, W., Krylova, S.M., Ma, J.H.Y., Chan, M., Walport, L.J., Wegman, D.W., Dack, K.N., McDonough, M.A., Krylov, S.N., Schofield, C.J. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase (2012) Journal of Medicinal Chemistry, 55 (5), pp. 2173-2184.

  15. Thalhammer, A., Aik, W., Bagg, E.A.L., Schofield, C.J. The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets (2012) Drug Discovery Today: Therapeutic Strategies, 9 (2-3), pp. e91-e100. 

 

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