Chemical and Structural Biology Lab
3D structures of protein/nucleic acid complexes
We are interested in studying protein-nucleic acid complexes in various contexts, such as RNA metabolism, viral replication, and cancer. We also aspire to be innovative in designing therapies using structures of protein/nucleic acid complexes as guides.
Our core technique is macromolecular X-ray crystallography. We are also interested in using other structural biology tools such as cryo-electron microscopy and NMR to obtain structural information of macromolecules.
We also take advantage of powerful techniques in chemistry to detect, analyse and probe biomolecules. Examples of techniques we frequently use are mass spectrometry and liquid chromatography. We also incorporate molecular biology techniques in our research.